The Clinical and Microbiological Study of the Effect of Minocycline Strip Locally Administrated on Adult Periodontitis / 대한치주과학회지

20 Subjects with clinical diagnosis of adult periodontitis with sites having average pocket depth of 4mm were selected for the study. After scaling and root planing of those sites, 30% minocycline-HCl contained in biodegradable device were inserted in one group, scaling and root planing was carried out in another group and the last group was without any periodontal treatment. the difference between the groups was determined by pocket depth, bleeding on probing, attachment level, distribution of subgingival plaque bacteria. Conclusion was made for the comparisons between baseline and 4 weeks and the groups. 1. In analysis of pocket depth, there was significant difference in scaling and root planing group only. 2. Both the scaling and root planing group and minocycline group showed significant decrease in bleeding on probing. 3. There was significant increase in the attachment level in scaling and root planing group ,but no difference was foundbetween the groups. 4. There was significant decrease in the total number of subgingival bacteria in all groups and the number of motile bacteria decreased significantly in the minocycline group. These results indicate that insertion of Minocycline-HCl at the base of periodontal pocket was useful as an additional aid of mechanical treatment at the point of periodontal pocket, bleeding on probing, attachment level, microbial distribution.

The comparative study between Dura mater and Guidor(R) in the healing of the classIII furcation defects in dogs / 대한치주과학회지

There are various treatment methods including barrier membranes in attaining periodontal regeneration and regaining the function of destructed periodontal tissues due to periodontal disease.Barrier membranes consist of non-Resorbable and resorbable types such as Dura mater and Guidor(R) used in the treatment of intrabony defects and classII furcation defects have been shown to be effectively increased the amount of new bone and cementum.In our study we used premolars with class III furcation defects created by removing the bone 4mm apically from CEJ in adult dogs and placed resorbable membrane Dura mater and Guidor(R) for the test group and flap operation was carried out for the control groups. The effect of membrane on junctional epithelium, alveloar bone, cementum, and gingival connective tisssue in the regeneration and healing potential of periodontal tissues was evaluated and healing results were evaluated histologically and histometrically 8 weeks following the surgical procedure. 1. In the clinical observation, there was no exposure of furcation defects in the control group, whereas slight membrane exposure was noted in the test group. 2. New bone was formed up to the level of the notch in the control group, whereas in the test group new bone formation was observed above the level of the notch. 3. New cementum was formed in both groups of the experiment. 4. The connective tissue observed between the new cementum and new bone in the test group were functionally orientated, compared to the irregular formation of connective tissues found in the control group. 5. Root resorption or ankylosis was not observed in any of the groups 6. The mean and median of the control group were 4.31% and 2.23% and for the Dura mater group were 27.85% and 15.57% respectively. There was no significant difference between Dura mater and the control group. 7. The mean and median of the control group were 4.31% and 2.23% and for the Guidor(R) group were 37.27% and 37.19% respectively. There was a significant difference in these two groups(P<0.05). 8. The mean and median of the Dura mater group were 27.85% and 15.57% and for the Guidor(R) were 37.27% and 37.19%. There was no significant difference between the two test groups. Thus, by using Dura mater and Guidor in classIII furcation defects, the predictable amount of periodontal ligament and alveolar bone regeneration may result.